Genetic Polymorphism of Avian Leukosis Virus Host Receptors in Korean Native Chickens and Establishment of Resistant Line

Avian leukosis virus (ALV) is a highly contagious retrovirus that causes tumors and has resulted in great economic loss worldwide owing to its high transmission rate. Various ALV viral subgroups exist, with infections occurring via specific host receptors. The susceptibility or resistance of avian species the ALV-A K determined by receptor, tumor locus A (tva) gene, while ALV-B depends on another B (tvb) gene. alleles tva tvb have primarily been identified China, but none detected Korea. We analyzed frequencies genotypes White Leghorn (WL), Korean Ogye (KO), native chicken (KNC) breeds assessed subgroups. In WL, both had various genotypes, including alleles, whereas KO, were dominant. KNC, mixed, addition, we showed there differences splicing pattern transcripts expression level within breeds. Finally, confirmed depended KO KNC in vitro infection embryonic fibroblasts ALV. These results highlight some individuals are naturally resistant A, B, will facilitate preservation economically superior traits through selective breeding.